Comparison of the NMR Spectroscopy Solution Structure of Pyranosyl-RNA and Its Nucleo-delta-peptide Analogue

For all biological systems, nature has chosen ribo- and deoxyribonucleic acids as its genetic building block. In order to understand this selectivity, the structures of the potential alternatives to the natural nucleic acids have to be investigated. We have determined the solution structures of pRNA and Nucleo-d-peptides by NMR spectroscopy. The structures pose important questions about the origin of helicity, stacking and inclination of these oligomers.

  • Ilin, S., Schlönvogt, I., Ebert, M.O., Jaun, B. & Schwalbe, H. Comparison of the NMR solution structures of pyranosyl-RNA and its nucleo-δ-peptides analogues. ChemBioChem, 3, 93-99 (2002)
  • Schwalbe, H., Wermuth, J., Richter, C., Szalma, S., Eschenmoser, A. & Quinkert, G. δ-Peptide analogues of pyranosyl-RNA, Part 2, Nucleo-δ-peptides derived from conformationally constrained nucleo-δ-amino acids: NMR study of the duplex formed by self-pairing of the (1’S, 2’S, 4’S)-(phba)-nucleo-δ-peptide-(AATAT). Helv. Chim. Acta 83, 1079-1107 (2000)