NMR structure determination of an RNA-protein-antibiotic complex

One of so far the biggest complexes of the ribosomal protein L11, ribosomal RNA, and the antibiotic thiostreptone was solved. This complex provides valuable indications on the mode of action of the antibiotic.

  • Jonker, H. R. A., Ilin, S., Grimm, S. K., Wöhnert, J. & Schwalbe, H. L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy. Nucleic Acids Res. 35, 441-454 (2007)